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OxyContin and Oxycodone are two different medications that work to relieve pain. Let's begin the discussion on the difference between OxyContin and Oxycodone. The main difference between them is in how they are released into the body. OxyContin is a controlled-release medication that gradually releases its active ingredient over time, thus providing long-lasting pain relief. In contrast, Oxycodone is typically used in shorter-acting forms such as tablets, capsules, and liquid solutions, making its effects shorter-lived. In this discu... more